Autoinflammatory Diseases in the Geriatric Population

Autoinflammatory disorders are inherited diseases of innate immunity leading to uncontrolled activation of the interleukin-1 pathway. The disorders are characterized by unprovoked recurrent inflammation affecting primarily the skin, as well as the serosal and synovial membranes. As innate immunity is the culprit, there are no autoantibodies or autoreactive T-cells to aid in the diagnosis and reactive amyloidosis is a potential severe long-term complication [1, 2].