The relationship between serum level of copper and ceruloplasmin and pathologic and clinical characteristics in early breast cancer patients.

e13504Background: The increase in serum copper and ceruloplasmin has been reported to positively related with the progress of advanced breast cancers. However, the role of copper and ceruloplasmin in early breast cancer(EBC) is unknown. Methods: 209 female patients that been diagnosed as EBC and treated within Xijing Hospital from Oct 2016 to Apr 2017 were included in the present study. The level of serum copper and ceruloplasmin were assayed using atomic absorption spectroscopy and immunoturbidimetry assay. respectively. The pathologic and clinical characteristics of patients such as age, pathologic type, etc. were analyzed by X test, t test and Pearson correlation analysis. p< 0.05 is significant. Results: After transforming copper and ceruloplasmin into binary variable (elevated and normal), age was both significant (p< 0.01). The different expression level of ER, PR , Ki67and molecular type, number and percent of metastatic lymph nodes were significant (p< 0.01). After correlation analysis, negative r...