Prophylactic and Therapeutic Effects of CCA on Rat Adjuvant Arthritis

It was found that CCA shows slight prophylactic and therapeutic effects on the secondary inflammation of rat adjuvant arthritis while it does not on the primary inflammatin. The therapeutic effect of CCA was characterized by its improving effect on the arthritic score when administered from day 21 to day 50 after adjuvant injection. The effect in this case was almost comparable to those of other anti-inflammatory drugs such as flufenamic acid, indomethacin or prednisolone. The mechanism of CCA upon rat adjuvant arthritis is different from those of known anti-inflammatory drugs and was assumed to be due to its immuno-modulating action.