5-HT2A receptors stimulate mitogen-activated protein kinase via H2O2 generation in rat renal mesangial cells

Eddie L. Greene,Odette Houghton,Georgiann Collinsworth,Maria N. Garnovskaya,Toshio Nagai,T Sajjad,Venugopala S. Bheemanathini,Jasjit S. Grewal,Richard V. Paul,John R. Raymond

5-HT2A receptors stimulate mitogen-activated protein kinase via H2O2 generation in rat renal mesangial cells

2000

Eddie L. Greene
Odette Houghton
Georgiann Collinsworth
Maria N. Garnovskaya
Toshio Nagai
T Sajjad
Venugopala S. Bheemanathini
Jasjit S. Grewal
Richard V. Paul
John R. Raymond

Serotonin (5-HT) stimulates mitogenesis in rat renal mesangial cells through a G protein-coupled 5-HT2A receptor. We tested the hypothesis that oxidants might be involved in the signal transduction...

Keywords:

Mitogen-activated protein kinase
Biochemistry
Biology
5-HT receptor
Serotonin
Signal transduction
Mesangial cell
Kinase
Receptor
Kidney
renal glomerulus

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