Analysis of diagnosis and therapy and correlation factors of 120 children with autoimmunity thyroid disease

Objective:To explore onset feature,clinical manifestations,the tendency of remission and recurrence,diagnosis and therapy of children with autoimmunity thyroid disease including Graves Disease(GD) and Hashimotos Thyroiditis(HT) and guide clinic better.Methods:The cases of pediatric endocrine clinic were collected from January 1994 to March 2008,which included 78 cases with HT and 42 cases with GD.According to their onset age,they were devided into prepuberty group and puberty group by Tanner staging.The morbidity rate of two groups,the level of thyroid hormone of HT patients onset and the level of antibody titer according to their onset age were observed.Pearson relationship analysis between the level of thyroid hormone and the level of antibody titer were made.Goitrous volume was determined by ultra-sonometry between GD group and HT group and compared.Results:(1) In 78 patients with HT the ratio of sex was 1:5.The level of thyroid hormone was different in HT group when they were initial patients.The titer of TGAb and TMAb in prepuberty patients was higher than that in puberty patients(P0.01).The level of FT3 and FT4 in HT group was positive correlation(P0.01).The titer of TGAb and TMAb was positive corre-lation(P0.01).(2)In 42 patients with GD the ratio of sex was 1:1.6.The prepuberty morbidity rate in HT group was higher than that in GD group(P0.05).(3)All patients had different degree goiter,but there was no significant difference between HT group and GD group(P0.05).Conclusion:The morbidity rate of girls is higher than boys' in HT group.The puberty morbidity rate is higher which is considered that is concernd with endocrine disorder.The titer of TGAb and TMAb in prepuberty patients is higher which suggest that the younger with disease,the longer of therapy and the more difficult to cure.