Rational discovery of a highly novel and selective mTOR inhibitor

Abstract Aided by Structure Based Drug Discovery (SBDD), we rapidly designed a highly novel and selective series of mTOR inhibitors. This chemotype conveys exquisite kinase selectivity, excellent in vitro and in vivo potencies and ADME safety profiles. These compounds could serve as good tools to explore the potential of TORC inhibition in various human diseases. ©2010 Elsevier Science Ltd. All rights reserved.