Mechanochemical approaches towards the in situ confinement of 5-FU anti-cancer drug within MIL-100 (Fe) metal-organic framework

We elucidate two annealing assisted mechanochemical methods to achieve one pot encapsulation of anti-cancer drug 5-Fluorouracil (5-FU) in the iron-based MIL-100 metal-organic framework (MOF). We compare the structural and physicochemical properties of drug@MIL-100 systems derived from in situ manual and vortex grinding, where the former exhibits a slower drug release due to stronger guest-host interactions.