Phenotype of blood lymphocytes in correlation with histological picture in thyroid gland of rats treated with potassium iodide.
2011
Having in mind the former results which confirmed the functional relationship
between the thyroid and the immune system, and the administration of
potassium iodide (KI) in the therapy of auto-immune diseases, we considered
it of interest to investigate the pathogenesis of KI induced experimental
thyroiditis, by studying the morphology of thymus, thyroid gland and spleen,
as well as the phenotype of lymphocytes in the thymus and peripheral blood in
relation to the expression of CD4 and CD8 molecules. The experiments have
been carried out on 30 male Wistar rats, divided in 3 groups. The first group
(n=10) received KI (225 μg/g, i.p.), the second group (n=10) received KI (675
μg/g, i.p.), while the third group (n=10) received sodium chloride (0.9%,
i.p.). The intensity of histological lesions in the thyroid gland, was
statistically significant (p<0.01) in KI treated groups, compared to the
controls. KI also significantly decreased rat body mass, and increased masses
of thymus and thyroid gland (p<0.05). No statistically significant difference
was found in thymocyte and peripheral blood CD4+ and CD8+ subpopulation
numbers between the groups. Our experiments suggest that KI, at least in some
doses could induce mild lymphocytic thyroiditis in rats, and that this
simple, practical and non-expensive model of experimental thyroiditis could
be of importance for further research.
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