Increased estrogen level can be associated with depression in males

Abstract Background Several studies have shown a positive association between depression and obesity; however the underlying mechanisms are not fully understood. It is not known if this association is driven by altered sex hormone levels in men due to increased BMI. Patients and methods Data were obtained from the LIFE-Adult-Study, a population-based cohort study. A total of 3925 men (2244   60 years) were included into analyses. Associations between BMI, sex hormones and depressive symptomatology according to CES-D score were evaluated. Results Obese men had compared to normal weight controls lower total testosterone (12.6 ± 4.7 vs 19.4 ± 5.5 nmol/L, p  60 years group) and free testosterone (249.0 ± 73.9 vs 337.2 ± 82.0 pmol/L, p  Conclusions Selected sex hormone parameters were significantly different in overweight and obese compared to normal weight males and certain differences could be seen between younger and older males. Depressive symptomatology was associated with increased estradiol levels in younger men, regardless of BMI.