ИЗУЧЕНИЕ ОСТРОЙ ТОКСИЧНОСТИ И АНТИОКСИДАНТНОЙ АКТИВНОСТИ ЭКСТРАКТА ЛИСТЬЕВ ОСИНЫ СУХОГО

The investigation of acute toxicity and antioxidant activity of the dry extract of leaves of aspen ordinary (Populus tremula L.) has been conducted. Acute toxicity has been not revealed after intragastric introduction to rats and mice in doses from 2500 mg/kg to 10000 mg/kg. Death of the animals has not been observed that did not allow to establish a lethal dose of the extract (LD50). In this connection, the studied preparation may be classified to Substance Hazard Class IV (low hazard substances) in compliance with State Standard GOST 12.1.007-76. High antioxidant (67,01,12%) and low prooxidant (25,11,68%) activity of the extract has been determined in the experiments in vitro. The obtained data indicate that biologically active substances of the extract being a direct antioxidant can suppress processes of peroxidation, and they don´t have an ability to induce lipid peroxidation of cell membranes directly.