Neonatal platelet reactivity and serum thromboxane B2production in whole blood: the effect of maternal low dose aspirin

Objectives Concern has been expressed about possible neonatal side effects after the use of maternal anti-platelet agents in pregnancy, particularly low dose aspirin treatment. We have studied neonatal platelet behaviour using whole blood techniques, and assessed the neonatal effect of the maternal ingestion of 60 mg aspirin daily. Design Cross sectional and randomised, double-blind, placebo-controlled. Setting University hospital. Subjects 1. Eight normal women, studied before conception, and their infants. 2. Twenty-four infants whose mothers had been randomised to receive either 60 mg aspirin daily, or placebo, in double-blind fashion