Label-free kinetic screening of proteins and virus binding in A 51,200 small-molecule library with a high-throughput ellipsometric scanning microscope

Using a label-free high-throughput optical scanning microscope we detected endpoints and binding kinetics of RNPC1a, Pyl(1&2) proteins and influenza virus A/PR/8/34 with a library of 51,200 small-molecule compounds from the NCI Developmental Therapeutics Program.