Brain hyperserotonemia causes autism-relevant social deficits in mice

Miho Tanaka,Atsushi Sato,S. Kasai,Yoko Hagino,Hiroko Kotajima-Murakami,Hirofumi Kashii,Yukio Takamatsu,Yasumasa Nishito,Masumi Inagaki,Masashi Mizuguchi,F. Scott Hall,George R. Uhl,Dennis L. Murphy,Ichiro Sora,Kazutaka Ikeda

Brain hyperserotonemia causes autism-relevant social deficits in mice

2018

Miho Tanaka
Atsushi Sato
S. Kasai
Yoko Hagino
Hiroko Kotajima-Murakami
Hirofumi Kashii
Yukio Takamatsu
Yasumasa Nishito
Masumi Inagaki
Masashi Mizuguchi
F. Scott Hall
George R. Uhl
Dennis L. Murphy
Ichiro Sora
Kazutaka Ikeda

Background Hyperserotonemia in the brain is suspected to be an endophenotype of autism spectrum disorder (ASD). Reducing serotonin levels in the brain through modulation of serotonin transporter function may improve ASD symptoms.

Keywords:

Psychology
Neuroscience
Developmental psychology
Neuropsychology
ASD
Autism spectrum disorder
Autism
Serotonin transporter
Endophenotype
Human genetics
Neurology
Serotonin

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