Recent advance in neurofibromatosis 2 with multi-type tumors
2019
Patients with type II neurofibromatosis often have multiple neurological tumors, including schwannoma, meningioma, astrocytoma and ependymoma, of which bilateral vestibular schwannoma is characteristic lesion. More than 90% of familial cases and 80%-85% of sporadic cases of type II neurofibromatosis have been confirmed to have neurofibromatosis II gene mutations in both tumor tissues and blood. This article reviews the relation of type II neurofibromatosis with different types of tumors, and the incidence, natural history and latest treatment strategies of type II neurofibromatosis, in order to provide new clues for diagnoses and treatments of patients with type II neurofibromatosis complicated with multi-type tumors.
Key words:
Neurofibromatosis II; Neurilemmoma; Meningioma; Glioma
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