Synthesis of L-Carnosine and its Applications in Biomedical Field

Chelation therapy is the administration of chelating agents to remove heavy metals from the body. Chelation therapy has a long history of use in clinical toxicology. For the most common forms of heavy metal intoxication – lead, arsenic, or mercury. A number of chelating agents are available are ethylenediaminetetraacetate (EDTA), dimercaptosuccinic acid (DMSA), 2,3-dimercapto-1-propanesulfonic acid (DMPS), alpha lipoic acid (ALA) and carnosine. They used in conventional and alternative medicine. In this work synthesize of carnosine has been studied. Carnosine (beta-alanyl-L-histidine) is a dipeptide of the amino acids beta-alanine and histidine. Carnosine is found naturally in healthy muscles, heart, brain, liver, kidneys and other tissues. N-Protected amino acids are important intermediates in organic synthesis. The use of N-phthalylamino acids as coupling agents in the synthesis of peptides has been studied by several groups of investigators. Hydrolysis of the phthalyl group with hydrazine at room temperature affords a direct synthesis of L-Carnosine. The molecular structures of the compounds were definite by using UV-Vis and FT-IR spectroscopy.