Guidelines rarely used GRADE and applied methods inconsistently: a methodological study of Australian guidelines

Abstract Objectives The GRADE approach is accepted methodology to assess the certainty of the evidence included in systematic reviews and clinical practice guidelines. The GRADE approach is endorsed globally, in Australia, the National Health and Medical Research Council advocated for the use of the GRADE approach in 2011. The purpose of this methodological review was to assess how GRADE has been adopted for Australian practice guidelines. Study design and setting This methodological review searched the of the National Health and Medical Research Council Clinical Practice Guidelines Portal from 2011 to 2018, in an effort to retrieve all practice guidelines available via this medium. Results 240 guidelines were retrieved authored by 51 different organisations. 15 guidelines followed GRADE methodology. Application of GRADE methods varied between guidelines, some misreported and altered aspects of the GRADE process. Guidelines that closely adhered to the guidance from the GRADE Working Group scored higher in domain 3 (rigour of development) of the AGREE II tool, indicating a positive linear relationship between GRADE adherence and rigour of development scores. Conclusion The results of our project suggest that the use of GRADE in Australian guidelines is increasing, however strategies to increase uptake and reporting within the guideline community need to be explored.