Biosynthetic origins of menisporopsin A.

Menisporopsin A, produced by Menisporopsis theobromae, shows antimalarial, antimycobacterial, and cytotoxic activities. Here, we report the first 13C incorporations at individual carbons of menisporopsin A using sodium [1-13C] and [2-13C] acetate. This result indicates that each of the subunits of the pentalactone menisporopsin A is assembled by a polyketide synthase.