Targeted hydrophobic anti-tumour medicine nanometre preparation and preparation method thereof

Disclosed is a targeted hydrophobic anti-tumour medicine nanometre preparation, comprising a hydrophobic anti-tumour medicine and a carrier with a mass ratio of 1:4-32.5, wherein the carrier is composed of 37.5-95.3 wt% of albumin and 4.7-62.5 wt% of hyaluronic acid-albumin conjugate, and the hyaluronic acid-albumin conjugate is prepared by albumin and hyaluronic acid with a molar ratio of 1:1-20. The method for preparing the nanometre preparation comprises: preparing the hyaluronic acid-albumin conjugate; formulating the carrier solution; formulating the medicine solution; and preparing the nanometre preparation. The particle diameter distribution of the nanometre preparation is relatively even, and the dispersibility is good, stable without aggregating. The particle diameter of the nanometre preparation redissolved after being freeze-dried substantially remains unchanged, and the recovery rate of the nanometre preparation is high and the efficacy is good after filtering (0.22 im) with a millipore filter.