Selection of miRNAs for clopidogrel resistance prediction

Abstract Aims This letter to the editor features a selection of possible miRNAs to be included into further development of smart diagnostic systems for clopidogrel resistance testing. Materials and methods The PharmGKB ( www.pharmgkb.org ), TargetScanHuman 7.2 ( www.targetscan.org/vert_72/ ) databases were scanned for a selection of relevant miRNAs. The designed graph includes the miRNAs that cover most of the genes responsible for clopidogrel resistance. Results Twenty-three miRNAs were selected to be included into the smart clopidogrel resistance testing systems: miR-15 (9/132 cases, 6.8%), miR-16, miR-195, miR-203, miR-424, miR-497 (8/132 cases, 6.0%, each), miR-30 (6/132, 4.5%), miR-19, miR-155 (4/132 cases, 3.0% each), miR-26, miR-27, miR-223 (3/132 cases, 2.3% each), miR-31, miR-96, miR-101, miR-128, miR-129, miR-137, miR-138, miR-143, miR-200, miR-455, miR-1271, (2/132 cases, 1.5% each). Conclusion This miRNAs selection can be used for scientific needs for further development of clopidogrel resistance testing systems.