The effect of high-flux hemodialysis on the inflammatory factors and serum brain natriuretic in hemodialysis patients with uremia

Objective To investigate the influence of the high-flux hemodialysis (HFD) on inflammatory factors[C-reactive protein (CRP), interleukin-6(IL-6), tumor necrosis factor-α(TNF-α)]and serum brain natriuretic (BNP) in patients before and after hemodialysis. Methods Fifty patients with MHD were enrolled in our hospital in 2013 and divided randomly into HD group (n=25), and HFD group (n=25). Serum CRP, IL-6, TNF-α, and BNP were measured in patients before and after the first hemodialysis session and after the treatment for 6 months later. Results Serum CRP, IL-6, and TNF-α in HD group after the first dialysis session and after the treatment for 6 months were statistically insignificant (P>0.05). In HD group, serum BNP was decreased after the first hemodialysis session and the treatment for 6 months later, the decreases was statistically significant (P 0.05). However, after the 6 mouths, the decreases were statistically significant( P<0.05). Serum BNP was decreased after the first hemodialysis session and the treatment for 6 months later, the decrease was statistically significant(P<0.01). Between two groups, the different time-point and the interaction of two groups and the different time-point, the discrepancy above them were statistically significant(P<0.01). Conclusions The high-flux hemodialysis can eliminate more inflammatory factors such as CRP, IL-6, TNF-α, and serum BNP in patients with uremia. Serum BNP Helps to adjust the dry weight in time, relieve cardiac load and reduce the incidence of heart failure. High-flux hemodialysis is one of the ways of treatment that reduce the morbidity of the heart failure. It can improve prognosis of the patients with MHD. Key words: Renal dialysis; Uremia/TH/ME; C-reactive protein/ME; Interleukin-6/ME; Tumor necrosis factor-alpha/ME; Natriuretic peptide, brain/ME