The role of osteoprotegerin and witamin D in thyroid pathology

Hormonal dysfunction of thyroid gland manifests, among other, in bone tissue disorders. The evaluation of changes in bone is possible not only by using the classical markers of bone turnover. Very interesting chemical compounds are osteoprotegerin and vitamin D; their serum concentration among patients with thyroid disorders can show the range of changes in bone metabolism. Osteoprotegerin possess an ability of reduction of bone resorption. Vitamin D has several "nonclassical" mechanisms of action, also the possibility of interaction with endogenous thyroid hormones. The aim of this study is to review the current literature concerning the role of osteoprotegerin and vitamin D in thyroid pathology.