Cutaneous toxicities of antiretroviral therapy for HIV Part II. Nonnucleoside reverse transcriptase inhibitors, entry and fusion inhibitors, integrase inhibitors, and immune reconstitution syndrome

Cutaneous manifestations of antiretroviral medications for HIV are common and potentially dangerous conditions encountered by dermatologists. Part II of this two-part series on the cutaneous effects of antiretroviral medications for HIV will discuss the four most recent classes of medications that have been developed and immune reconstitution syndrome—an important diagnostic consideration when evaluating a dermatologic patient who is taking antiretroviral medications. Learning objectives After completing this learning activity, participants should be able to recognize common and dangerous cutaneous adverse effects related to nonnucleoside reverse transcriptase inhibitors and entry and fusion inhibitors, determine which of these toxicities need further investigation or medication cessation, and understand the dermatologic manifestations of immune reconstitution syndrome and their importance in the differential diagnosis of a drug reaction in HIV-positive patients.