H 2 S mediates O 2 sensing in the carotid body

Sgenerationinthecarotidbody seems to require interaction of CSE with hemeoxygenase-2,which generates carbon monoxide. CSE is also expressed in neo-natal adrenal medullary chromaffin cells of rats and mice whosehypoxia-evoked catecholamine secretion is greatly attenuated byCSE inhibitors and in CSE knockout mice.