Modelling of miniature endplate current

From analyzing the mathematical model of miniature endplate current (MEPC) generation described previously an optimal set of parameters was found providing the best match between the results of stimulation and experimentally obtained findings. The time course of MEPC in the controls, after cholinesterase inhibition, and following a bungarotoxin-induced reduction in the density of unoccupied cholinoreceptors were described within the framework of the model. This model also statisfactorily describes voltage-dependent current decay, and the currentvoltage relationship of MEPC, as well as the kinetics of “giant” MEPC observed during cholinesterase inhibition. The influence of the parameters of the model on “model” MEPC is also examined. The good match between the results of modelling and experimental findings leads to the conclusion that the model gives a true picture of different processes contributing to the generation of MEPC.