Особенности прогнозирования при остром коронарном синдроме у мужчин и женщин

Aim. To study the gender-specific perspectives of in-hospital outcome prognosis in acute coronary syndrome (ACS) patients. Material and methods. In total, 1035 consecutive patients with acute myocardial ischemia were included in the study. The role of clinical and laboratory parameters in ACS prognosis was assessed by binary logistic regression. Results. Under age of 65 years, ACS in males resulted in Q-myocardial infarction (MI) more often (23.4%) than in females (9.7%; p<0.001). In patients over 65, ACS structure was similar for both genders. Women were hospitalized with cardiovascular pathology or diabetes mellitus in anamnesis more often; females under 65 used anti-ischemic medications in arterial hypertension (AH) and coronary heart disease (CHD) therapy more actively. In univariate analysis of baseline parameters, predictors of fatal ACS outcome might be divided into three groups: risk factors (RF) with gender-independent outcome impact; RF with varying impact; RF with gender-specific impact. In a multivariate model, fatal outcome probability assessment was more effective in males than in females: explained dispersion was 72.4% and 48.5%, area under curve – 0.99 and 0.93, respectively. Conclusion. Gender-specific study on RF and their predictive value is optimal for predicting in-hospital outcomes of ACS.