PREVENTION AND TREATMENT OF HEMORRHAGIC CYSTITIS IN NONRELATIVE ALLOGENETIC HEMATOPOIETIC STEM CELL TRANSPLANTATION

Objective To explore the characteristics,risk factors,effective prevention and treatment of hemorrhagic cystitis(HC)in patients after nonrelative allogenetic hematopoietic stem cell transplantation(Allo-HSCT)receiving routine prophylaxis for HC.Methods 10 patients with hemotologic malignancy after nonrelative Allo-HSCT were studied,we adopted routine prophylaxis for HC,graft versus host disease(GVHD)and cytomegalovirus(CMV)infection.The relationship between HC and transplantation type or other clinical features was analyzed.The curative effect was observed.Results Eight cases showed early HC,the median onset time of HC was 26.88 days after transplantation,the median persistence time was 19.3 days;five cases were combined with aGVHD and CMV infection,one case only appeared aGVHD,another two were nothing.Seven cases were complete remission,one case dead.Conclusion After full prevention,most HC in patients after nonrelative Allo-HSCT were early onset,no severity and better therapeutic efficacy,which may be closely related to donor type,HLA match,aGVHD and CMV infection.