Effect of the Duration of UV Irradiation on the Anticoagulant Properties of Titanium Dioxide Films

Recently, UV irradiation has been reported as a new approach to significantly improve the anticoagulant properties of titanium dioxide (TiO2) films by suppressing fibrinogen adsorption and platelet adhesion. This study focuses on how fibrinogen adsorption of and platelet adhesion to TiO2 films is affected by the duration of UV irradiation. Furthermore, this study intends to describe the link between the suppression effect and the changes in the TiO2 films nature caused by photogenerated reactive oxygen species (ROS). First, we performed UV irradiation in different atmospheres as model 1 to determine the effect of oxygen gas on the anticoagulant properties of TiO2 films. The results showed that the suppression of platelet adhesion induced by UV irradiation depended on the presence of oxygen gas, indicating that ROS were photogenerated, and the ROS-induced surface change was related to the improvement in the anticoagulant ability. Then, we fabricated three other types of TiO2 samples in air by varying the U...