Response to Letter Regarding Article, “Ventricular Phosphodiesterase-5 Expression Is Increased in Patients With Advanced Heart Failure and Contributes to Adverse Ventricular Remodeling After Myocardial Infarction in Mice”

Peter Pokreisz,Sara Vandenwijngaert,Glenn Marsboom,Olivier Gheysens,Pieter Vermeersch,Xiaoshun Liu,Hilde Gillijns,Marijke Pellens,Luc Schoonjans,Stefan Janssens,Johan Vanhaecke,An Van Den Bergh,Paul Herijgers,Virginie Bito,Ilse Lenaerts,Liesbeth Biesmans,Karin R. Sipido,Alfons Van Lommel,Erik Verbeken,Cornelius J. Busch,Emmanuel Buys,Kenneth D. Bloch

Response to Letter Regarding Article, “Ventricular Phosphodiesterase-5 Expression Is Increased in Patients With Advanced Heart Failure and Contributes to Adverse Ventricular Remodeling After Myocardial Infarction in Mice”

2009

We appreciate the comments by Cingolani et al on a possible involvement of Na+/H+ exchanger (NHE-1) in signaling mechanisms downstream of cGMP that can mediate cardioprotection after myocardial infarction. These authors previously reported that NHE-1 expression and activity are increased after myocardial infarction in rats (as a result of myocardial acidosis) and that sustained …

Keywords:

Ventricular remodeling
Acidosis
Heart failure
Myocardial infarction
Diabetes mellitus
Cardioprotection
cGMP-specific phosphodiesterase type 5
Cardiology
Phosphodiesterase
Internal medicine
Medicine
in patient

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