EFFECTIVENESS OF ANTIHYPERTENSIVE AGENTS AMONG HYPERTENSIVE PATIENTS OF NEPAL

These investigations compare the effectiveness of antihypertensive agents among hypertensive patients. It was an open label, prospective and comparative study carried out in the Out - patient depar tment at BPKIHS, Dharan, Sunsari, Nepal. Patients of either sex aged between 25 - 80 years suffering from mild to moderate hypertension were randomly selected. In this study indicate various types of antihypertensive drugs for the manageme nt of hypertension like Calci um channel blockers (amlodipine ), Angiotensin Converting enzyme inhibitors (Enalpril), beta adrenergic blocker (metoprolol, propranolol, atenolol), Angiotension receptor blocker (Losartan), Diuretics (Spironolactone, Fureso mide). In this study, o ut of 40 patients of stage 1 hypertension: 18 % patients were treated with ARBs, 30 % patients were treated with CCBs, 15 % patients with CCBs + diuretics, 8 % patients with β - blockers + ARBs, 10 % with ACE inhibitors and 12.5 % patients were treated with β – blockers + CCBs. Similarly, out of 15 patients of stage 2 hypertensive pati ents, 6 % patients were treated with ARBs + diuretics, 13 % patients with ARBs + β blockers, 20 % with CCBs + diuretics, 20 % with β blockers + ACE inhibitor s and 40 % patients were treated with CCBs + ARBs. Three drug combined therapy is more effective as compared to two drug combined therapy and mono therapy. In this study, male hypertensive patients were observed more susceptible with severe hypertension as compared to female hypertensive patients. The reason corresponding to this statement might be more stressful life style and frequent smoking habit as well as more alcohol consumption habit of male as compared to female.