Childhood condyloma acuminatum: association with genital and cutaneous human papillomaviruses

We studied 25 children, age 7 months to 12 years 6 months, with anogenital warts, and their parents. In most children the warst were localized in the anal area, in 3 of 18 girls perianally and on the vulva, and in 4 girls exclusively on the vulva. Southern blot hybridization studies disclosed an association of condylomata wiht human papillomaviruses (HPV) 6 and 11 in 74% and HPV 2 in 17.4% of patients. The clinical features were similar in warts induced by genital and cutaneous HPVs. Even the HPV 2-associated warts in the vulva of two girls were typical of condyloma acuminatum