E-2 (4- (4-chlorine-1,2-difenilbut-1-enil) phenoxy) ethanol and pharmaceutical compositions of the same.

The present invention relates to E-2- [4- (4-Chloro-1, 2-diphenylbut-1-enyl) phenoxy] ethanol (I) which has serum cholesterol lowering properties and pharmaceutical compositions thereof. Compound (I) is useful for reducing serum cholesterol levels and in the treatment of atherosclerosis. It is also potentially useful in hormone replacement therapy (HRT). The invention also provides a pharmaceutical composition comprising E-2- [4- (4-chloro-1, 2-diphenylbut-1- enyl) phenoxy] ethanol or a pharmaceutically acceptable ester thereof as an active ingredient together with a pharmaceutically carrier. acceptable. The invention also provides a method for lowering serum cholesterol levels, a method comprising administering to an patient in need of such treatment an effective amount of E-2- [4- (4-chloro-1, 2-diphenylbut-1-enyl) phenoxy] ethanol or a pharmaceutically acceptable ester thereof.