Study of pathological characteristics in Kunming mice and Babl/c mice infected with toxoplasma gondii

[Objective]To study the pathological changes in Kunming mice and Babl/c mice infected with toxo-plasma gondii. [Methods] Kunming mice and Babl/c mice were infected with toxoplasma tachyzoite by intraperi-toneal injection. Then, the infection rate and pathological histology were observed in infected mice. The control mice only received an injection of same amount of saline. [Results]The two kind of mice were susceptible to toxoplasma gondii. The Kunming mice showed infection at 2nd-3rd day postinoculated, and died at 7th～10th day postinfection. The mortality was 95.00%. The hepatocyte denaturation and necrosis were observed. And a lot of toxoplasma tachy-zoites could be obtained from abdominal cavity. But in Babl/c mice, the onset of the sickness was at 4th ～ 5th day postinfection. Most mice could live through the acute stage of infection. The mortality was only 10.00%. The toxo-plasma antigen could be detected in mouse liver and brain, Although the cyst could not be found. All control mice were normal in the research time. [Conclusion] The susceptibility of toxoplasma infection in these two kinds of mice were different. The Babl/c mouse probably is a good model to research the toxoplasma infection and immunity.