NocturnalRapidEyeMovementSleepLatencyforIdentifying PatientsWithNarcolepsy/HypocretinDeficiency

RESULTS ShortREML(! 15minutes)duringNPSGwashighlyspecific(99.2%[95%CI,98.5%100.0%]of516and99.6%[95%CI,99.1%-100.0%]of735)butnotsensitive(50.6%[95%CI, 46.3%-54.9%]of516and35.7%[95%CI,10.6%-60.8%]of14)forpatientswithnarcolepsy/ hypocretindeficiencyvspopulation-basedcontrolsorallpatientswithsleepdisordersundergoinganocturnalsleepstudy(areaunderthecurve,0.799[95%CI,0.771-0.826]and0.704[95% CI,0.524-0.907],respectively).Inpatientswithcentralhypersomniaandthusahighpretest probabilityfornarcolepsy,shortREMLremainedhighlyspecific(95.4%[95%CI,90.4%-98.3%] of132)andsimilarlysensitive(57.4%[95%CI,48.1%-66.3%]of122)fornarcolepsy/hypocretin deficiency(areaunderthecurve,0.765[95%CI,0.707-0.831]).Positivepredictivevalueinthis highpretestprobabilitysamplewas92.1%(95%CI,83.6%-97.0%).