Imunomodulator Potention Of Alkaloid Sambiloto (Andrographis paniculata L) To IFNγ and CD4+ Response After Infected by Salmonella typhimurium on The Rat

The aim of this research was to prove scientifically immunomudulator activities ofalkaloid sambiloto to adaptive immunity response in helping maintain the immune systemin common cold condition was caused by lack of immune system because of transmissionof infectious disease through examination of Interferon gamma (IFNγ) and sel helper(CD4+) that specific immune response. The research methods was activity of alkaloidsambiloto to innate immune response, that proved on 125 rats (Rattus norwegicus) thatdivided into 5 groups, which were control group (K), and 4 treatment groups. Controlgroup (P0) and treatments were infected by Salmonella typhimurium intraperitoneally105 CFU (P1,P2 and P3) then were given by alkaloid in various doses ( 0 mg/kg bw.,3,78 mg/kg bw., 7,56 mg/kg bw, and 11,34 mg/kg bw) for 10 days. The parameters thatobserved were IFNγ and CD4+. The research data that obtained were analyzed by one wayanava, if there was a different, then advanced analyze was done by smallest significantdifferential test. Research result was alkaloid sambiloto can decrease IFNγ and CD4+start from day 2 and back to normal after infected by Salmonella typhimurium.