CCR5-Δ32 gene polymorphism is related to celiac disease and autoimmune thyroiditis coincidence in patients with type 1 diabetes

Abstract Aim The aim of the study was to assess the relationship between CCR5 -Δ32 polymorphism and the coincidence of celiac and autoimmune thyroid diseases with type 1 diabetes mellitus (T1D) in children. Methods 420 children with T1D aged 15.5 ± 3.0 years and 350 healthy controls were studied. Characterization of CCR5 -Δ32 genotypes (rs333) was analyzed by polymerase chain reaction (PCR). Results The allele frequency was significantly different in diabetic children as compared to the healthy controls (p  CCR5 -Δ32 genotypes due to celiac and autoimmune thyroid diseases. The risk of celiac disease for patient carriers of the 32-bp deletion was more than threefold higher than for noncarriers (OR = 3.490; 95% CI = 1.357–8.859; p = 0.009). Similar results were obtained in the case of autoimmune thyroiditis. The risk of autoimmune thyroiditis for patient carriers of the 32-bp deletion was also more than threefold higher than for noncarriers (OR = 3.466; 95% CI = 1.754–6.849; p = 0.0004). Conclusions The findings of our studies suggest that the CCR5 -Δ32 polymorphism is associated with type 1 diabetes mellitus and the Δ32 allele increases the risk of celiac disease and autoimmune thyroid disorders in patients with T1D.