Similar to influenza virus (PRV) containing particles haemagglutinin produced within a plant

A method for producing similar to influenza virus particles (VLPs) in a plant comprising: a) introducing a nucleic acid comprising a nucleotide sequence encoding a hemagglutinin deinfluenza (HA) operably linked to a regulatory region active in the plant within the plant, or unaporcion thereof, b) incubating the plant under conditions that permit expression of the nucleic acid, thereby producing the VLPs, c) harvesting the plant, and d) purifying the VLP, wherein the VLP are in a size range of 80-300 nm.