Hyperuricosuric calcium nephrolithiasis

The hyperuricosuric calcium stone former is a unique clinical entity. Although an impressive number of clinical and epidemiologic studies implicate hyperuricosuria in calcium stone formation, the exact physicochemical mechanism by which uric acid affects calcium oxalate crystallization has not been proved. Allopurinol decreases stone recurrences and is the drug of choice for patients with isolated HCN.