Structure-based design and synthesis of benzimidazole derivatives as dipeptidyl peptidase IV inhibitors.
2008
A novel series of non-covalent, benzimidazole-based inhibitors of DPP-4 has been developed from a small fragment hit using structure-based drug design. A highly versatile synthetic route was created for the development of SAR, which led to the discovery of potent and selective inhibitors with excellent pharmaceutical properties.
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