PP090-MON THE EFFECT OF DIFFERENT NUTRTIONAL SUPPLEMENT ON LIVER HYPERTROPHY AND BODY COMPOSITION AFTER PORTAL VEIN EMBOLISATION

Rationale: Residual liver (FLR) after liver resection should be more than 30% of the total liver (TLV). Portal vein embolisation can hypertrophise the FLR. The aim was to investigate the effects of supplementation on FLR hypertrophy, tumor volume changes (TV), body composition and nutritional status. Methods: Until now 20 patients with liver tumors, whose FLR after the planned liver resection was less than 30% of the TLV measured by CT-volumetry enrolled. In addition to the anthropometric and laboratory tests, bioimpedance analysis was performed to assess nutritional status and body composition. Patients in the arginine group received 2×200ml oral nutritional supplement (ONS), which contained 2×3 g arginine for the period of liver hypertrophy. Patients in the control group were supplemented with an ONS without arginine. Eight weeks after PVE control every measurements were performed again. Results: In the “arginine” group liver hypertrophy rate was higher (FLRArg: 15.37% vs. FLRc: 10.98%) and tumor volume growth was significantly (p < 0.05) lower in the arginine group than in the control group (TVArg: 10.38 cm3 vs. TVc: 93.91 cm3). Laboratory parameters indicating nutritional status changes became better in both groups after FLR hypertrophy. Body composition changes became better in both group after period of hypertrophy. Conclusion: Arginine supplementation may positively affect FLR hypertrophy and may reduce tumor volume growth after portal vein embolisation. Nutritional supplementation positively affects nutrition status and body composition, not only in undernourished patients.