Comparison of tachocomb and tissudura in terms of adverse effects and complications in duraplasty in rats

AIM This study aimed to compare two synthetic graft materials, TachoComb®, a fibrin sealant composed of collagen, fibrinogen, thrombin and aprotinin and TissuDura®, a collagen-based biomatrix. MATERIAL AND METHODS Thirty Sprague-Dawley rats were randomly divided into three groups with 10 animals in each group. A dural defect was created on the left parietal bone of each animal, and the dural defect was repaired using either TachoComb® (TachoComb group) or TissuDura® (TissuDura group). Sham animals did not receive any dural graft. After 21 days of follow-up, the brain was dissected, and inflammation, oedema, gliosis and foreign body reaction in the bone and parenchymal tissue were investigated histopathologically. RESULTS The TachoComb group showed significantly greater inflammation, gliosis and parenchymal foreign body reaction compared with the sham group. By contrast, the TissuDura group significantly had lower lesser gliosis and insignificantly lesser inflammation in the bone and parenchymal foreign body reaction compared with the TachoComb group. CONCLUSION In conclusion, our results suggest that TissuDura® may be considered more biocompatible than TachoComb® in duraplasty.