Extractive Spectrophotometric estimation of Eplerenone using Acid dyes in Tablet dosage forms

Three simple, accurate, rapid and sensitive methods (A, B and C) have been developed for the estimation of Eplerenone in its pharmaceutical dosage forms. The methods A, B and C are based on extraction of colored ionassociation complex in chloroform formed between Eplerenone and BTB, BCG and BPB in potassium hydrogen phthalate buffer (pH-2.4). Which shows λmax at 410nm 414nm and 425nm respectively. Beer’s law is obeyed in the concentration range of 1.25-55μg/mL of Eplerenone for method A, 5-45μg/mL for method B, and 2.5-45μg/mL for method C. Results of analysis for all the methods are validated statistically and by recovery studies. The proposed methods are economical, sensitive and can be used for routine analysis of Eplerenone in bulk and tablet formulation.