Amyloid deposition and ApoE4 carriers in idiopathic normal pressure hydrocephalus

It is known that idiopathic normal pressure hydrocephalus (iNPH) can co-morbid with Alzheimer disease (AD). Previous studies, probing amyloid (Aβ) deposition by cortical biopsy during a ventriculo-peritoneal shunt, have shown that Aβ deposition was found in 40~45 % of iNPH patients. However, the reason for this high prevalence is not well understood. Therefore, the objective of this study was to investigate whether the prevalence of the Aβ deposition in iNPH is explainable by a simple overlap of the AD pathology in general population, or is modified by some specific effects of iNPH.