Anti ulcer activity of Naravelia zeylanica leaves extract.

The objective of present study is to evaluate the anti ulcer activity of ethanol extract of leaves of Naravelia zeylanica. The ethanol extract of N.zeylanica was investigated for its anti ulcer activity against aspirin plus pylorus ligation induced gastric ulcer in rats, HCl -Ethanol induced ulcer in mice and water immersion stress induced ulcer in rats. The antiulcer activity was assessed by determining and comparing gastric volume, free acidity and ulcer inhibition in aspirin plus pylorus ligation induced gastric ulcer model. The number of lesions in HCIEthanol induced peptic ulcer model and mean score value of ulcer inhibition in water immersion stress induced ulcer model. A significant antiulcer activity was observed in all the models. Pylorus ligation model showed significant (P<0.01) reduction in gastric volume, free acidity and ulcer index as compared to control. Also extract showed 89.71% ulcer inhibition in HCl- Ethanol induced ulcer and 95.3% ulcer protection index in stress induced ulcer. This present study indicates that Naravelia zeylanica leaves extract have potential anti ulcer activity in the three models tested.