Clinical study of Ruiyun procedure for hemorrhoids combined with Xiaozhiling injections in treatment of hemorrhoids complicated with human immunodeficiency virus infection

Objective To explore the efficacy of Ruiyun procedure for hemorrhoids (RPH) combined with Xiaozhiling injection in the treatment of hemorrhoids complicated with human immunodeficiency virus (HIV)infection and its influence on cellular immune function. Methods Clinical data of 76 hemorrhoid patients, including 36 positive HIV and 40 negative HIV, undergoing RPH combined with Xiaozhiling injections in our center from January 2010 to December 2012 were retrospectively analyzed. Clinical efficacy and cellular immune function preoperative day 1, postoperative day 7, 30 were compared between positive and negative groups. Results Recurrence rates of positive group and negative group postoperative 6 months were 22.2% (8/36)and 22.5% (9/40), postoperative 1 year were 30.6% (11/36)and 30.0% (12/40)without significant differences (all P>0.05). Morbidity of postoperative complication was also not significantly different between two groups (P>0.05). According to HIV classification, peripheral lymph cell ratio, CD4 count, CD4/CD8, white blood cell count and neutrophil ratio were not significantly different between preoperative day 1 and postoperative day 7 in both groups (all P>0.05). Decreasing velocity and amplitude of CD4 in both groups from high to low was HIV Ⅲ, HIV Ⅱ, HIV Ⅰ, HIV-, while after 30 days the increase of CD4 from high to low was HIV-, HIV Ⅰ, HIV Ⅱ, HIV Ⅲ, which were significantly different as compared to postoperative day 7 (all P<0.05). Conclusions RPH combined with Xiaozhiling injection in the treatment of hemorrhoids complicated with HIV infection is effective and safe. Postoperative inhibited cellular immune function can recover quickly. Key words: Hemorrhoids; Human immunodeficiency virus; Ruiyun procedure hemorrhoids; Hardener; Clinical efficacy; Cellular Immune Function