Relationship of polymorphism of megsin C2093T and C2180T with IgA nephrology:a Meta-analysis

Objective To analyze the relation between the polymorphism of megsin C2093T and C2180T gene and IgA nephropathy.Methods Studies related to the relation of polymorphism of megsin C2093T and C2180T to IgA nephropathy were authenticated from databases including Medline,Embase and Cochrane Library from Jan.1980 to Aug.2010.The cited literature of obtained articles and some core English and Chinese medical journals relevant to nephropathy were also searched by hand(2000 to Aug.2010).The data were analyzed by RevMan 5.0 software.Results Five papers were finally included,meta-analysis results showed that there was statistical difference between megsin 2093C allele and risk for IgA nephropathy [odds ratio(OR) = 1.20,95% CI 1.04 to 1.40].No statistical difference existed between megsin 2093CC genotype and risk for IgA nephropathy(OR=1.18,95% CI 0.90 to 1.55).In Asian subgroups,there was significant difference between megsin 2093C allele and risk for IgA nephropathy(OR=1.19,95% CI 1.01 to 1.40),while no significant association existed between megsin 2093CC genotype and risk for IgA nephropathy(OR=1.19,95% CI 0.88 to 1.61).Also,no significant difference was revealed in the total meta-analysis between the megsin 2180C allele and risk for IgA nephropathy(OR=0.89,95%CI 0.72 to 1.10) or CC genotype and risk for IgA nephropathy(OR=1.04,95%CI 0.69 to 1.56).Moreover,no significant difference was found between megsin 2093 and 2180C allele and IgA nephropathy progression(OR=0.89,95%CI 0.69 to 1.15;OR=0.84,95%CI 0.48 to 1.46,respectively).There was also no significant difference between megsin 2093 and 2180CC genotype and IgA nephropathy progression(OR=0.80,95%CI 0.42 to 1.49;OR=0.79,95%CI 0.32 to 1.93,respectively).Significant difference was found between the 2093T-2180T haplotype and IgA nephropathy progression(OR=0.54,95%CI 0.33 to 0.87).Conclusion Megsin 2093C allele is the susceptible gene of IgA nephropathy,while megsin 2093 genotype,2180 allele or genotype are not.The 2093T-2180T haplotype plays a protective effect on the progression of IgA nephropathy.