Morphological changes induced in HEp-2 cells by Salmonella typhimurium porins.

: The effects of different doses of Salmonella typhimurium porins were investigated on human laryngeal epithelial (HEp-2) cells by fluorescence and transmission electron microscopy. The changes observed in microfilament organization suggested an involvement of cytoskeleton in the cell response. Furthermore, morphologic phenomena characterized by ultrastructural membrane modifications also involved the nuclear membrane.