An analysis of gene expression relationships between periodically expressed genes in the hela cells

The availability of increasingly accumulated time-series expression profiles has provided the data structures to study the temporal relationship between genes. The aims of the study were to explore the modes of relationship between the genes periodically expressed in human HeLa cell cycle, and to reversely engineer the dynamic networks of gene transcription. We also studied the phase-specific properties of the genetic relationships by decomposing the whole network into the sub-networks according to the cell cycling phases. The results demonstrated that the gene-gene relationships within a same phase or between different phases followed different modes.