Unlocking a more comprehensive assessment of diet with continuous, chronic blood glucose and complete hemodynamic monitoring in rodents

New technology was employed in a novel way to monitor the effect of diet change on continuous blood glucose in addition to standard hemodynamic parameters. A new telemetry implant (HD-S11-F2, DSI) enables researchers to collect and transmit data at a different radio-frequency (18MHz) than the traditional 455KHz implants. While a second frequency allows for social housing and tighter density of research subjects, in this experiment the 18MHz device was paired with a continuous glucose telemetry implant (HD-XG, DSI) in the same animal. Implantation of two devices in a single animal allowed us to measure blood pressure, ECG, arterial blood glucose, body temperature and activity in a single rat. Six male Sprague Dawley rats were implanted with 2 telemetry implants that each required an arterial site for sensor placement. The HD-XG sensor was placed in the descending abdominal aorta and the device body was located IP. The HD-S11-F2 was inserted in the femoral artery and the catheter tip was advanced to the abd...