SISTER CHROMATID EXCHANGE

EARLY RESULTS .... .. .. ...... ..... ......... ........ ... ....... ....... . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 83 Sister Chromatid Exchange in Meiosis 1 83 Sister Chromatid Exchange in Somatic Cells 1 84 Isolabeling 1 86 Sister Chromatid Exchanges-Spontaneous or Induced? 1 86 RESULTS FROM NEW METHODS FOR DETECTING SISTER CHROMA TID EXCHANGES ... .. .. .... ... .. ..... ... ..... .. ... .. ... ........ ... .. ... 1 86 Reasons for Differential Staining ... ... .. ..... .. ..... ... ... ...... ........ ........ ... ..... ... ... .. ... . 1 87 Harlequin Chromosomes and Chromosome Structure .... ... .. . 1 89 Multiple sister chromatid exchanges 1 90 Autoradiographic image spread . .... ..... ........ ....... ... ... ..... ... .. .. 1 90 Labeling for more than one replication cycle .... .. ... ... ....... ...... ...... ... ... . 1 90 The Question 0/ Spontaneous Levels 0/ Sister Chromatid Exchanges ....... ..... ...... .. .. 1 9 1 Location 0/ Sister Chromosome Exchanges in the Chromosome ....... .... ... .. ... 1 93 Sister Chromatid Exchanges and Human Genetic Diseases .. ... ... ......... ......... 1 93 Sister Chromatid Exchanges as Indicators 0/ Mutagenic Carcinogens .. .. ... .... .. ... .. .. 1 94 Lesions Responsible for Sister Chromatid Exchange Formation . .. .... .... .... 1 96 CONCLUSION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 97