Hepatic acyl-CoA:diacylglcyerol acyltransferase (DGAT) overexpression, diacylglycerol, and insulin sensitivity.

Lipid accumulation in organs is strongly associated with insulin resistance. However, the causal relationship is uncertain. For hepatic steatosis, this relationship has given rise to many studies and theories. One hypothesis, suggested as unifying (1), posits simply that accumulation of diacylglycerol induces hepatic insulin resistance by interfering with insulin signaling.